minimum of constrained nonlinear multivariable function algorithm Search Results


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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by <t>multivariate</t> multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.
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Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.

Journal: Lancet

Article Title: Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study

doi: 10.1016/S0140-6736(12)62203-X

Figure Lengend Snippet: Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). The p values test whether the association between maternal 25(OH)D concentration and offspring BMC differs by trimester of measurement. Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model, was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D concentrations. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.

Article Snippet: To increase efficiency and keep selection bias to a minimum, we used multivariate multiple imputation (Stata, version 11 MP2) to impute missing values of covariables for eligible participants, according to the method described by Royston.

Techniques: Concentration Assay

Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester and sex of offspring (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.

Journal: Lancet

Article Title: Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study

doi: 10.1016/S0140-6736(12)62203-X

Figure Lengend Snippet: Mean differences in offspring bone-mineral content in relation to maternal 25(OH)D concentrations in pregnancy, by trimester and sex of offspring (A) Offspring total body bone-mineral content (total body less head measured; n=3960). (B) Offspring spine bone-mineral content (n=3196). Model A adjusted for maternal age and offspring age and sex. Model B, the main confounder-adjusted model was model A plus adjustment for maternal education, ethnic origin, parity, smoking in pregnancy, and body-mass index before pregnancy. Model C was model B plus adjustment for potential mediation by birthweight, gestational age, and offspring height, lean mass, and fat mass. Model D was model B plus adjustment for potential mediation by offspring 25(OH)D. Values missing for covariables were calculated by multivariate multiple imputation. 25(OH)D=25-hydroxyvitamin D. Predicted 3rd=all women with 25(OH)D concentrations adjusted to 34 weeks' gestation.

Article Snippet: To increase efficiency and keep selection bias to a minimum, we used multivariate multiple imputation (Stata, version 11 MP2) to impute missing values of covariables for eligible participants, according to the method described by Royston.

Techniques: